Hereditary deficiency of the seventh component of complement.
نویسندگان
چکیده
منابع مشابه
Hereditary deficiency of the second component of complement (C'2) in man.
The serum complement system is composed of at least eight or nine interacting proteins (1, 2). The complete system is required for the reactions of immune cytolysis, immune hemolysis, bacteriolysis, and the lysis of certain tumor cells (1, 3-7). There are other complement dependent systems that do not require all nine components. The reactions of immune adherence and erythrophagocytosis require...
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The first recognized human kindred with hereditary deficiency of the fifth component of complement (C5) is described. The proband, a 20-year-old black female with systemic lupus erythematosus since age 11, lacked serum hemolytic complement activity, even during remission. C5 was undetectable in her serum by both immunodiffusion and hemolytic assays. Other complement components were normal durin...
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An 18-yr-old black woman in good general health was found to lack serum hemolytic complement activity. The sixth component of complement (C6) was undetectable by functional assay of serum or plasma and by immunoprecipitin analysis of serum. Functional titers of all other complement components were normal. The absence of C6 in the patient's serum could not be accounted for by a circulating C6 in...
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Hereditary angioedema (HAE), a rare autosomal dominant disorder, was first described in the late 19th century. The disease remained poorly understood and without therapeutic options until the latter half of the 20th century. Advances in the understanding of immunologic and hematologic pathways have shed light on HAE, a disease characterized by painful and unpredictable recurrent attacks of nonp...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1975
ISSN: 0021-9738
DOI: 10.1172/jci108170